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. 2016 May 10;6(5):652–659. doi: 10.1016/j.stemcr.2016.04.009

Figure 1.

Figure 1

Definition of a High Wnt Stem Cell Signature

(A) Experimental setup. LSK cells from various APC mutant mice were sorted from bone marrow, transduced with Cre-GFP retrovirus and GFP-transduced cells were again sorted and used for further experiments.

(B) Principal component analysis plots of all 15 biological samples used in this study. The percentage of variance captured by each of the first three principal components is indicated.

(C) Hierarchical clustering of the various APC mutants and WT HSCs indicating the top 50 differentially expressed genes and changes in gene expression.