Figure 4.

High Levels of Wnt Signaling Enhances Multilineage Differentiation

Transduced LSK cells from Apc WT and 15lox/15lox were co-cultured with OP9 stromal cell line for 14 days, then were harvested, and assessed by flow cytometry for myeloid (CD11b and Gr1⁺) and B cell development (B220 and CD19⁺). Error bars represent the SD of six samples from individual mice from two independent experiments. Asterisks indicate statistical significance as follows: ^∗p < 0.05, and ^∗∗p < 0.01 (Mann-Whitney U test).