Table 4.
Multivariable Analysis: Predictors of 21-day spontaneous survival in 613 patients with non-acetaminophen-induced Acute Liver Failure.
| Univariate (N=632) | Multivariate (N=613, c=0.700) | |||||
|---|---|---|---|---|---|---|
| Variable | Odds Ratio | 95% CI | p-value | Odds Ratio |
95% CI | p-value |
| Age | 0.984 | 0.972 – 0.996 | 0.0086 | 0.99 | 0.977 – 1.002 | 0.11 |
| Male | 1.291 | 0.893 – 1.867 | 0.17 | 1.618 | 1.083 – 2.416 | 0.019 |
| Mechanical ventilation | 0.837 | 0.518 – 1.350 | 0.47 | |||
| Renal replacement therapy | 0.861 | 0.592 – 1.253 | 0.44 | |||
| Vasopressors | 0.519 | 0.355 – 0.757 | 0.0007 | 0.602 | 0.4 – 0.904 | 0.014 |
| MELD | 0.929 | 0.907 – 0.952 | <0.001 | 0.929 | 0.906 – 0.952 | <0.0001 |
| Hypothermia | 1.051 | 0.481 – 2.293 | 0.90 | 0.962 | 0.394 – 2.347 | 0.93 |
- Final model included age, gender, vasopressors, MELD and hypothermia
- 19 patients had missing data
- The multivariable model had a c-statistic of 0.70, Hosmer-Lemeshow p=0.1577