Table 2.
Overview of PIK3CA exon 9 mutations in cervical tissue specimens as assessed by HRM‐sequencing
| A. Cross‐sectional series stratified by histological grade | B. CIN2 and CIN3 stratified by known duration of preceding hrHPV infection | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| PIK3CA exon 9 mutation | Normal (n = 105) n (%) | CIN1 (n = 154) n (%) | CIN2 (n = 144) n (%) | CIN3 (n = 209) n (%) | SCC (n = 28) n (%) | AdCA (n = 7) n (%) | Early (n = 9) n (%) | Advanced (n = 37) n (%) | |
| CDS change | Amino acid change | ||||||||
| c.1624G>A | p.E542K | 0 (0) | 0 (0) | 0 (0) | 1 (0.5) | 5 (17.9) | 0 (0) | 0 (0) | 0 (0) |
| c.1624G>C | p.E542Q | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 1 (3.6) | 0 (0) | 0 (0) | 0 (0) |
| c.1633G>A | p.E545K | 0 (0) | 0 (0) | 0 (0) | 4 (1.9) | 5 (17.9) | 1 (14.3) | 0 (0) | 2 (5.4) |
| c.1637A>G | p.Q546R | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 1 (3.6) | 0 (0) | 0 (0) | 0 (0) |
| Overall | 0 (0) | 0 (0) | 0 (0) | 5 (2.4) | 12 (42.9) | 1 (14.3) | 0 (0) | 2 (5.4) | |
AdCA, adenocarcinoma; Advanced, CIN2 (n = 3) and CIN3 (n = 34) from women with a preceding hrHPV infection ≥5 years; CDS, coding DNA sequence; CIN, cervical intraepithelial neoplasia; Early, CIN3 from women with a preceding hrHPV infection <5 years; SCC, squamous cell carcinoma.