Table 3.
Levels of metabolites in the plasma and the urine at baseline and after treatment with VEDT
| Metabolite | Baseline Mean (SD), μM | Post-Treatment Mean (SD), μM | P value |
|---|---|---|---|
| Plasma α-tocopherol | 21.19 (5.02) | 19.58 (6.36) | 0.5699 |
| Plasma γ-tocopherol | 4.47 (2.16) | 3.59 (1.39) | 0.431 |
| Plasma δ-tocopherol | 0.25 (0.01) | 0.24 (0.01) | 0.4786 |
| Plasma α-tocotrienol | 0 (0) | 0.03 (0.02) | <0.0001 |
| Plasma γ-tocotrienol | 0 (0) | 0.04 (0.03) | <0.0001 |
| Plasma δ-tocotrienol | 0 (0) | 0.09 (0.09) | <0.0001 |
| Plasma α-CEHC | 0.05 (0.04) | 0.06 (0.06) | 0.6595 |
| Urine α-CEHC | 4 (7.21) | 3.05 (3.84) | 0.7936 |
| Plasma γ-CEHC | 0.43 (0.25) | 0.39 (0.25) | 0.7555 |
| Urine γ-CEHC | 15.21 (13.54) | 20.14 (12.44) | 0.5102 |
| Plasma δ-CEHC | 0.12 (0.08) | 6.17 (4.33) | <0.0001 |
| Urine δ-CEHC | 8.24 (6.92) | 90.91 (28.63) | <0.0001 |
| Plasma α-CMBHC | 0.27 (0.13) | 0.31 (0.13) | 0.5900 |
| Urine α-CMBHC | 8.52 (18.59) | 6.08 (14.85) | 0.8044 |
| Plasma γ-CMBHC | 0.05 (0.06) | 0.04 (0.01) | 0.6348 |
| Urine γ-CMBHC | 0.48 (0.37) | 0.85 (0.6) | 0.1623 |
| Plasma δ-CEHC | 0.03 (0.03) | 3.02 (2.65) | 0.0003 |
| Urine δ-CEHC | 1.03 (1.07) | 57.71 (37.4) | 0.0005 |
Post-treatment levels were sampled on days 8 or 14 of treatment approximately 12 hours after the last dose. CEHC, carboxyethyl hydroxychroman; CMBHC, carboxymethylbutyl hydroxychroman.