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. Author manuscript; available in PMC: 2016 Jul 11.
Published in final edited form as: Gene Ther. 2015 Aug 23;23(1):78–85. doi: 10.1038/gt.2015.78

Figure 2.

Figure 2

miRNA-mediated PPARδ knockdown in hematopoietic stem cells ameliorates the development of atherosclerosis in −/− mice. Lethally irradiated −/− mice were randomly divided into two groups (12 mice each) and transplanted with bone marrow cells infected with the indicated viruses. The mice were fed with an atherogenic diet for 8 weeks beginning 4 weeks post bone marrow transplantation and then killed. The lesion size in the aorta root was examined using oil red O staining as described in Materials and Methods. (a) Representative images of oil red O staining of the aortic root. (b) Statistical analysis of the atherosclerotic lesion sizes in two groups (**P<0.01). (c) Immunostaining with anti-CD68 antibody to show the content of macrophages in lesion areas. (d) Statistical analysis of the CD68-positive staining of two groups (**P<0.01).