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. 2016 Apr 15;11(6):389–397. doi: 10.1080/15592294.2016.1172160

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Figure 4. — Schematic representation of the distribution of H2AK119ub and the proteins studied across developmental stages. Nuclear pattern distribution of H2AK119ub (A), RYBP, YAF-2 (B), L3MBTL2 and L3MBTL1 (C) at all stages of pre-implantation development. Levels H2AK119ub (A) at the zygote stage are subdivided into 4 ProNuclear (PN) stages to reflect dynamic changes in the pattern and levels of the mark. Color representation: Light blue indicates low levels of enrichment whereas darker blue is representative of high levels and specific localization in foci (dots in the diagram). Nucleolar-like bodies (NLBs) in the oocyte, zygote, and 2-cell stage embryos are shown as red circles in the nucleus.