Table 4.
Differential DNA methylation of the 5 CpG sites annotated to ABCG1, PHOSPHO1, SOCS3, SREBF1 and TXNIP in T2D compared with non-diabetic subjects in pancreatic islets, adipose tissue, skeletal muscle, and blood.
| DNA methylation (%) |
||||||||
|---|---|---|---|---|---|---|---|---|
| CpG | Gene | Non-diabetic | T2D | Delta | P-value | Q-value* | Tissue | Ref. |
| cg06500161 | ABCG1 | 56.7 ± 2.3 | 57.9 ± 2.8 | 1.2 | 0.032 | 0.135 | Blood | |
| cg06500161 | ABCG1 | 43.9 ± 5.3 | 47.7 ± 5.2 | 3.8 | 0.025 | 0.123 | Adipose tissue | Nilsson et al. |
| cg02650017 | PHOSPHO1 | 26.3 ± 5.7 | 24.2 ± 5.4 | −2.1 | 0.020 | 0.123 | Skeletal muscle | |
| cg11024682 | SREBF1 | 52.0 ± 5.8 | 59.5 ± 8.4 | 7.5 | 0.045 | 0.160 | Pancreatic islets | Dayeh et al. |
| cg19693031 | TXNIP | 63.4 ± 4.3 | 59.4 ± 6.6 | −4.0 | 0.020 | 0.123 | Skeletal muscle | |
| cg19693031 | TXNIP | 67.6 ± 4.5 | 64.7 ± 6.5 | −3.0 | 0.023 | 0.123 | Blood | |
| cg19693031 | TXNIP | 56.7 ± 10.4 | 44.8 ± 10.4 | −11.9 | 0.0006 | 0.016 | Pancreatic islets | Dayeh et al. |
*
FDR was calculated for 25 tests.