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. 2016 Jun 1;11(6):464–474. doi: 10.1080/15592294.2016.1151586

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Figure 3. — Differentially methylated CpGs between HCV-HCC vs. NIV-HCC. (A) Principal component analysis of the methylation data was plotted using the first 2 principal components (PC1 = 64% and PC2 = 6.65%). Each dot represents a sample (blue for HCV-HCC and green for NIV-HCC). (B) Unsupervised hierarchical clustering of β-values for differentially methylated loci. Blue and green blocks on the top of the maps represent HCV-HCC (n = 13) and NIV-HCC (n = 10), respectively. (C) Mean methylation level for all 7 differentially-methylated loci among HCV-HCC (left) and NIV-HCC (right). (D) The top IPA network involving differentially methylated genes. Red and blue genes indicate differentially methylated genes and connected cancer related genes, respectively. (E) The top associated cellular functions with numbers of differentially-methylated genes.