Table 3. Logistic regression analysis for the association between FGF23 and left ventricular mass or left ventricular ejection fraction.
| FGF23 t1 | FGF23 t2 | FGF23 t3 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| OR | OR | 95% CI | OR | 95% CI | |||||
| Dependent variable: LVH | |||||||||
| model 1 | G1/G2 | 1 | (ref) | 1.66 | (0.83–3.32) | 2.85 | (1.30–6.25) | ** | |
| G3a | 1 | (ref) | 1.22 | (0.69–2.15) | 2.03 | (1.11–3.71) | * | ||
| G3b | 1 | (ref) | 1.57 | (0.78–3.17) | 1.70 | (0.87–3.30) | |||
| G4 | 1 | (ref) | 10.7 | (1.03–112) | * | 12.6 | (1.29–123) | * | |
| model 2 | G1/G2 | 1 | (ref) | 1.66 | (0.83–3.31) | 2.82 | (1.28–6.19) | * | |
| G3a | 1 | (ref) | 1.29 | (0.72–2.32) | 2.50 | (1.33–4.71) | ** | ||
| G3b | 1 | (ref) | 1.69 | (0.83–3.45) | 1.83 | (0.93–3.62) | |||
| G4 | 1 | (ref) | 13.6 | (1.24–149) | * | 17.6 | (1.66–185) | * | |
| model 3 | G1/G2 | 1 | (ref) | 1.54 | (0.75–3.17) | 2.67 | (1.16–6.18) | * | |
| G3a | 1 | (ref) | 1.25 | (0.69–2.27) | 2.39 | (1.25–4.56) | ** | ||
| G3b | 1 | (ref) | 1.7 | (0.79–3.41) | 1.68 | (0.84–3.36) | |||
| G4 | 1 | (ref) | 13.0 | (1.18–143) | * | 16.1 | (1.52–171) | * | |
| model 4 | G1/G2 | 1 | (ref) | 1.40 | (0.67–2.90) | 2.36 | (1.00–5.58) | ||
| G3a | 1 | (ref) | 1.23 | (0.67–2.26) | 2.37 | (1.23–4.56) | * | ||
| G3b | 1 | (ref) | 1.63 | (0.78–3.40) | 1.69 | (0.84–3.40) | |||
| G4 | 1 | (ref) | 13.2 | (1.13–154) | * | 16.65 | (1.51–184) | * | |
| model 5 | G1/G2 | 1 | (ref) | 1.48 | (0.61–3.60) | 2.84 | (1.05–7.64) | * | |
| G3a | 1 | (ref) | 1.85 | (0.89–3.84) | 3.01 | (1.37–6.61) | ** | ||
| G3b | 1 | (ref) | 1.88 | (0.72–4.90) | 1.67 | (0.69–4.03) | |||
| G4 | 1 | (ref) | 15.0 | (0.89–254) | 14.50 | (0.88–240) | |||
| Dependent variable: Low LVEF | |||||||||
| model 1 | G1/G2 | 1 | (ref) | 1.30 | (0.49–3.42) | 3.44 | (1.24–9.59) | * | |
| G3a | 1 | (ref) | 2.19 | (0.97–4.93) | 3.19 | (1.37–7.41) | ** | ||
| G3b | 1 | (ref) | 1.69 | (0.77–3.72) | 1.85 | (0.87–3.92) | |||
| G4 | 1 | (ref) | 2.93 | (0.30–29.1) | 5.23 | (0.59–46.1) | |||
| model 2 | G1/G2 | 1 | (ref) | 1.21 | (0.45–3.22) | 3.25 | (1.16–9.13) | * | |
| G3a | 1 | (ref) | 2.11 | (0.93–4.81) | 3.29 | (1.38–7.86) | ** | ||
| G3b | 1 | (ref) | 1.63 | (0.73–3.62) | 1.78 | (0.83–3.82) | |||
| G4 | 1 | (ref) | 3.51 | (0.35–35.6) | 6.48 | (0.71–59.1) | |||
| model 3 | G1/G2 | 1 | (ref) | 0.87 | (0.30–2.49) | 2.60 | (0.85–7.90) | ||
| G3a | 1 | (ref) | 1.92 | (0.81–4.58) | 3.17 | (1.27–7.92) | * | ||
| G3b | 1 | (ref) | 1.40 | (0.57–3.45) | 1.34 | (0.57–3.19) | |||
| G4 | 1 | (ref) | 2.48 | (0.21–28.9) | 4.59 | (0.46–46.4) | |||
| model 4 | G1/G2 | 1 | (ref) | 0.85 | (0.29–2.46) | 2.57 | (0.82–8.11) | ||
| G3a | 1 | (ref) | 2.06 | (0.86–4.94) | 3.49 | (1.39–8.80) | ** | ||
| G3b | 1 | (ref) | 1.46 | (0.59–3.62) | 1.39 | (0.58–3.30) | |||
| G4 | 1 | (ref) | 3.21 | (0.25–41.1) | 5.81 | (0.52–64.4) | |||
| model 5 | G1/G2 | 1 | (ref) | 0.70 | (0.17–2.85) | 3.64 | (0.87–15.30) | ||
| G3a | 1 | (ref) | 1.15 | (0.39–3.34) | 2.71 | (0.95–7.73) | |||
| G3b | 1 | (ref) | 1.39 | (0.42–4.62) | 1.18 | (0.39–3.61) | |||
| G4 | 1 | (ref) | 0.68 | (0.03–13.6) | 1.44 | (0.10–20.0) | |||
Model 1, adjusted for sex, age and eGFR; model 2, adjusted for variables in model 1 plus corrected calcium and inorganic phosphate; model 3, adjusted for variables used in model 2 plus CRP, and diuretic use; model 4, adjusted for variables used in model 3 plus systolic blood pressure and history of hypertension; model 5, adjusted for variables used in model 3 plus intact PTH, although fewer patients were included in this analysis.
* and ** indicate p<0.05 and P<0.01, respectively;
t1, t2, and t3 indicate the lowest, middle, and highest tertile, respectively. OR indicates odds ratio, and ref indicates referent.