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. 2016 Jul 6;11:913–925. doi: 10.2147/CIA.S107285

Figure 2.

Figure 2

Percent change from baseline in biomarkers of bone turnover (median, Q1, Q3) and BMD (mean, 95% CI) after up to 24 months of teriparatide treatment and at LOCF in patients with osteoporosis at high risk of fracture in Japan.

Notes: Biomarkers for bone formation were PINP (A) and bone ALP (B) and for bone resorption were CTX-I (C) and TRACP5b (D). The mean (SD) baseline values were: PINP 51.49 (59.49) ng/mL; bone ALP 19.37 (17.45) IU/L; CTX-I 0.22 (0.16) ng/mL; and TRACP5b 451.50 (245.29) mU/dL. BMD was measured at the lumbar spine (E), femoral neck (F), and total hip (G). *P<0.05 for the increase from baseline at each time point.

Abbreviations: bone ALP, bone-specific alkaline phosphatase; BL, baseline; BMD, bone mineral density; CI, confidence interval; CTX-I, collagen type I cross-linked C telopeptide; LOCF, last observation carried forward; PINP, procollagen type I N-terminal propeptide; Q1, first quartile; Q3, third quartile; SD, standard deviation; TRACP5b, tartrate-resistant acid phosphatase 5b.