Table 1.
Baseline demographics, disease characteristics, comorbidities, and previous or concomitant osteoporosis treatments of patients with osteoporosis at high risk of fracture in Japan
| Characteristics | Patients (N=1,847) |
|---|---|
| Age | |
| Mean (SD), years | 75.4 (9.1) |
| Median (min, max), years | 76 (31, 101) |
| 30 to <50 years, n (%) | 19 (1.0) |
| 50 to <65 years, n (%) | 210 (11.4) |
| 65 to <75 years, n (%) | 531 (28.7) |
| 75 to <85 years, n (%) | 839 (45.4) |
| ≥85 years, n (%) | 248 (13.4) |
| Height, mean (SD), cm | 148.0 (7.8) |
| Weight, mean (SD), kg | 47.3 (8.9) |
| Females, n (%) | 1,711 (92.6) |
| Menopause status, n (%) | |
| Premenopause | 9 (0.5) |
| Postmenopause | 1,554 (90.8) |
| Unknown | 148 (8.6) |
| Age at menopause, mean (SD), yearsa | 48.9 (4.8) |
| Current smoker, n (%)b | 35 (1.9) |
| Alcohol consumption (>3 U/d), n (%)b | 29 (1.6) |
| History of fracture, n (%)b | 1,180 (63.9) |
| Past surgery for fracture, n (%) | 243 (13.2) |
| History of proximal femoral fracture in patients’ parents, n (%)b | 76 (4.1) |
| Vertebral fractures, n (%) | 962 (52.1) |
| 1 | 370 (20.0) |
| 2 | 230 (12.5) |
| ≥3 | 362 (19.6) |
| Nonvertebral fractures, n (%) | 238 (12.9) |
| 1 | 191 (10.3) |
| 2 | 36 (1.9) |
| ≥3 | 11 (0.6) |
| BMD, % of YAM, n (%)b | |
| ≥80% | 133 (7.2) |
| 70 to <80% | 150 (8.1) |
| <70% | 670 (36.3) |
| CKDb stage, n (%) | |
| 1 | 194 (10.5) |
| 2 | 710 (38.4) |
| 3 | 350 (18.9) |
| 4 | 30 (1.6) |
| 5 | 3 (0.2) |
Notes:
a
Information on age at menopause was available for 598/1,554 postmenopausal female patients.
b
Information was not available on history of fracture for 224 patients; history of femoral fracture in patients’ parents for 872 patients; BMD for 894 patients; CKD for 560 patients; current smoking status for 410 patients; and alcohol consumption for 442 patients from the 1,847 patient cohort.
Abbreviations: BMD, bone mineral density; CKD, chronic kidney disease; min, minimum; max, maximum; n, number; SD, standard deviation; YAM, young adult mean.