Table 2.

The pharmacokinetic parameters of warfarin (mean ± SD, n=5)

Group	WN	WO	WFN	WFO
AUC0–t (ng/mL⋅min)	2,304,674.80±638,144.86	1,175,817.25±192,837.94a	1,919,361.85±243,763.82	1,224,894.50±413,691.34b
MRT0–t (minutes)	606.31±66.18	718.31±40.74c	685.20±62.08	606.13±52.15b,d
t1/2Z (minutes)	1,221.34±528.65	1,546.99±778.57	1,104.66±544.20	884.79±498.02
Tmax (minutes)	132±65.73	432±107.33a	432±262.91c	240±278.21
Cmax (ng/mL)	2,308.36±414.84	1,085.02±293.33a	2,030.68±272.57	1,429.50±321.17b

Notes:

^aCompared with the WN group P<0.01.

^bCompared with the WFN group P<0.05.

^cCompared with the WN group P<0.05.

^dCompared with the WO group P<0.01.

Abbreviations: WN, healthy rats after a single administration of warfarin; WO, rats with biliary drainage after a single administration of warfarin; WFN, healthy rats after the administration of warfarin and ferulic acid; WFO, rats with biliary drainage after the administration of warfarin and ferulic acid; AUC_0–t, area under the curve from 0 to time; C_max, peak plasma concentration; MRT_0–t, mean retention time; t_1/2Z, terminal halftime; T_max, time to C_max.