Table 2.
Changes in body weight, food intake, and water intake in the experimental groups
| Groups | Body weight (g)
|
Food intake (g)
|
Water intake (mL)
|
|||
|---|---|---|---|---|---|---|
| Day 1 | Day 28 | Day 1 | Day 28 | Day 1 | Day 28 | |
| Control | 194.10±4.27 | 231.92±5.87 | 21.29±1.22 | 28.19±1.67 | 30.18 ±4.05 | 35.98±2.80 |
| RA 120 mg/kg | 193.28±4.39 | 226.99±10.04 | 21.59±2.11 | 28.31±2.12 | 30.57±3.37 | 39.27±5.17 |
| RA 160 mg/kg | 192.78±4.68 | 212.43±7.50 | 22.81±2.54 | 29.88±2.33 | 31.25±3.49 | 36.27±3.78 |
| RA 200 mg/kg | 194.80±4.98 | 215.52±8.13 | 21.82±2.20 | 28.39±2.59 | 31.95±3.68 | 39.22±5.31 |
| STZ | 202.81±3.43 | 174.18±5.02 | 36.02±2.70 | 54.26±3.26 | 149.20±6.45 | 202.99±6.67 |
| RA 120 mg/kg | 201.45±4.47 | 174.25±4.84 | 36.01±2.07 | 52.67±3.58 | 150.15±7.19 | 207.25±6.23 |
| RA 160 mg/kg | 203.96±4.38 | 176.67±5.79 | 36.82±1.99 | 52.05±3.05 | 152.49±6.88 | 208.91±7.94 |
| RA 200 mg/kg | 202.12±4.54 | 177.42±6.86 | 36.84±2.26 | 49.08±4.56 | 155.33±8.99 | 204.44±7.86 |
| HFD | 330.17±5.40 | 389.82±8.95 | 56.48±2.53 | 77.99±3.28 | 38.05±3.86 | 42.85±3.71 |
| RA 120 mg/kg | 331.94±4.42 | 365.26±6.65* | 56.88±2.69 | 74.90±3.66 | 39.79±3.83 | 42.05±5.71 |
| RA 160 mg/kg | 330.31±5.75 | 359.34±9.09* | 55.52±4.26 | 73.02±3.43 | 37.12±4.71 | 43.85±4.40 |
| RA 200 mg/kg | 334.00±8.21 | 356.81±9.75* | 58.00±2.63 | 68.13±4.01 | 39.79±3.83 | 44.82±5.02 |
Notes: The values are shown as the mean ± SEM (n=8).
*
P<0.05 compared with the untreated group (vehicle).
Abbreviations: RA, rosmarinic acid; STZ, streptozocin; HFD, high-fat diet; SEM, standard error of the mean.