Table 1.
Patient characteristics
| Characteristics | Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | Patient 6 |
|---|---|---|---|---|---|---|
| Age (years) | 67 | 68 | 76 | 76 | 68 | 79 |
| Sex | F | M | F | M | M | F |
| Height (cm) | 164 | 160 | 156 | 165 | 178 | 160 |
| Weight (kg) | 55 | 89 | 51 | 60 | 47 | 50 |
| FEV1 (%pred) pre-NO | 0.74 | 0.87 | 0.84 | 0.59 | 0.77 | 0.61 |
| FEV1 (%pred) post-NO | 0.49 | 0.77 | 0.87 | 0.59 | 0.8 | 0.56 |
| FVC (L) pre-No | 2.52 | 2.78 | 2.32 | 2.96 | 2.7 | 2.16 |
| FVC (L) post-NO | 1.92 | 2.3 | 2.4 | 3.25 | 2.9 | 2.03 |
| FEV1/FVC (%) pre-NO | 29 | 34 | 36 | 20 | 29 | 28 |
| FEV1/FVC (%) post-NO | 25 | 33 | 36 | 18 | 28 | 28 |
| LTOT (L/min) | 2 | 2 | 2 | 2 | 1.5 | 2 |
| Hours LTOT/d | 24 | 24 | 16 | 24 | 22 | 16 |
| Smoking history (pack-years) | 25.5 | 90 | 25.8 | 50 | 57.5 | 71.25 |
| SpO2 (%) pre-NO | 96 | 98 | 99 | 95 | 94 | 96 |
| SpO2 (%) post-NO | 97 | 98 | 99 | 96 | 94 | 100 |
| sPAP (mmHg) screening | 52 | 47 | 44 | 39 | 56 | 43 |
| Blood pressure (mmHg) pre-NO | 135/80 | 110/60 | 116/62 | 130/70 | 122/70 | 152/80 |
| Blood pressure (mmHg) post-NO | 140/86 | 134/74 | 170/80 | 170/80 | 120/70 | 158/80 |
| MethHb pre-NO | 0.6 | 0.4 | 0.8 | 0 | 0.4 | 0.9 |
| MethHb post-NO | 0.6 | 0.3 | 0.2 | 0 | 0.5 | 0.7 |
Abbreviations: %pred, percentage of predicted; F, female; FEV1, forced expiratory volume in 1 second; FEV1/FVC, Tiffeneau–Pinelli index; FVC, forced vital capacity; LTOT, long-term oxygen therapy; M, male; NO, nitric oxide; post-NO, post-nitric oxide inhalation; pre-NO, pre-nitric oxide inhalation; SpO2, oxygen partial pressure; sPAP, systolic pulmonary arterial pressure; methHb, methemoglobin.