. Author manuscript; available in PMC: 2016 Jul 11.

Published in final edited form as: Hepatology. 2014 Jan 27;59(3):1084–1093. doi: 10.1002/hep.26564

Table 2.

Demographic data in patients with liver failure.

Patient ID	Gender	Race	Age	Year Enrolled In Study	Medications Taken	Total Dose	Duration	Date Last taken expressed as number of days from enrolment	Concomitant Disease
ALF-1	F	African American	65	2007	INH	300 mg/day	8 mo	−5
					Pyridoxine	50	8 mo	−5
					Motrin
ALF-2	F	African American	63	2001	RMP	300 mg/day	4 mo	−2
					INH	300 mg/day	1 mo	−136
					PZA	2000 mg/day	4 mo	−2
					HCTC	50 mg/day	36 mo	−2
ALF-3	F	African American	21	1998	INH	300 mg/day	5 mo	−16
ALF-3	F	African American	21	1998	acetaminophen
ALF-4	M	White	30	2001	PZA	2000 mg/day	30 days	−8
					Motrin	400 mg/day		−18
					RMP	600 mg/day	30 days	−8
					Multivitamin
					acetaminophen
					INH	300 mg/day	4 mo	−44
ALF-5	F	White	59	2002	Premarin
					Darvocet
					Trazodone
					Paxil
					INH	300 mg/day	2 mo	−19
ALF-6^a	F	Other	41	2004	Dilatin	200 mg/day			epilepsy, developmental delay with meningitis
					Multivitamin
					Reglan	10 mg/day		−51
					Protonix	40 mg/day		−51
					Duragesic Patch	25 mg/day		−51
					Colace
					Zoloft	50 mg/day		−51
					Carbamazepine
ALF-7	F	White	39	2006	INH	300 mg/day	6 mo	−25	migraines, irritable bowel syndrome, obesity, cholecystectomy
					Ortho Evra (Patch)	50 mg/day
					Reglan
					Atenolol
ALF-8	F	White	45	2008	INH	300 mg/day	80 days	−14	obesity
					Vitamin B6		80 days	−14
					Paxil	20 mg/day		−31
ALF-9	F	White	66	2008	Advair		12 mo		diabetes
					Vitamin B6	50 mg/day	8 mo	−47
					Tamoxifen	20 mg/day		−4
					INH	300 mg/day	8 mo	−47
					Crestor	20 mg/day	24 mo	−4
					Singulair	10 mg/day	12 mo
					Pyridoxine	50 mg/day	8 mo	−47
					Levothyroxine	137 μg/day	12 mo
					PZA	500 mg/day	8 mo	−47
					Spirvia	18 μg/day	12 mo
					RMP	300 mg/day	8 mo	−47
ALF-10	F	White	31	1998	INH		4 mo
ALF-11	M	White	28	1998	Vitamin B6		6 mo	−84
ALF-11	M	White	28	1998	INH		6 mo	−84
ALF-12	F	White	47	2004	PZA	250 mg/day	21 days	−5	brain cysts, postcraniotomy seizures, optic neuritis, hypertension
					RMP	600 mg/day	21 days	−5
					Pepcid
					Ethambutol	1200 mg/day	21 days	−5
					Depakote	1000 mg/day		−5
					Tegretol	1200 mg/day	36 mo	−5
					INH	300 mg/day	21 days	−5
					Metoprolol	50 mg/day		−5
					Carbamazepine	100 mg/day
					Dexamethasone	1 mg/day	21 days
ALF-13	F	Other	17	2000	Tylenol	2600 mg/day	1 day	−4
					Amoxicillin	500 mg/day	1 day	−4
					Compazine	10 mg/day	1 day	−4
					INH	300 mg/day	6 mo	−18
ALF-14	F	Asian	27	2001	INH	300 mg/day	6 mo	−7
ALF-15	M	White	22	1998	PZA	1250 mg/day	1 mo	−8
					acetaminophen
					RMP	600 mg/day	1 mo	−8
					Ethambutol	1200 mg/day	1 mo	−8
					INH	300 mg/day	21 days	−16
ALF-16	F	White	35	2003	Ethambutol		21 days	−4
					PZA		21 days	−4
					INH		21 days	−4
					RMP		21 days	−4
ALF-17	F	Asian	37	2003	INH		5 mo
					Amoxicillin		5 days	−25
					Cefzil		X days
					Acyclovir			−8
ALF-18	M	White	53	2007	INH	300 mg/day	90 days	−15	diabetes, high cholesterol, hypertension
					Diovan	160 mg/day	24 mo	−15
					Tenuate sr	75 mg/day	3 mo	−15
					Crestor	20 mg/day	7 mo	−15
ALF-19	M	Native Hawaiian/Other Pacific Islander	51	2010	PZA		3 mo	−5	chronic viral hepatitis B, hypertension
					INH		3 mo	−5
					RMP		3 mo	−5
					Ethambutol		3 mo	−5
					Atenolol	50 mg/day		−1

Bold indicates patients who tested positive for the presence of anti-INH antibodies. ALF = Acute liver failure. M = male; F = female; INH = isoniazid; RMP = rifampicin; PZA = pyrazinamide; mo = months. Concomitant disease were anything from collagen/vascular disease, chronic liver disease, endocrine/diabetes, psychiatric disease, neurological, hypertension, heart disease, renal, pulmonary disease, substance abuse, GI disease, HIV/AIDs, intravenous drug use at any time in past, other, or none.