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. Author manuscript; available in PMC: 2016 Jul 11.
Published in final edited form as: Free Radic Biol Med. 2014 Apr 12;72:23–40. doi: 10.1016/j.freeradbiomed.2014.03.039

Figure 4.

Figure 4

Iron loading (log scale) in transfused children with congenital dyserythropoietic anemia (CDA), Diamond-Blackfan anemia (DBA), pyruvate kinase deficiency (PK), sickle cell disease (SCD) and thalassemia major (TM). Children with ineffective erythropoiesis (black symbols) and those with effective (red symbols) erythropoiesis have similar iron loading of the liver at an early age. Children with ineffective or markedly decreased erythropoiesis (TM, CDA, DBA) have comparatively more loading of their pancreas and heart, consistent with NTBI-mediated loading. Dashed lines indicate upper limit of normal ranges.