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. 2016 Jun 6;14(2):1054–1060. doi: 10.3892/mmr.2016.5368

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Copyright: © He et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of GCs on the histological morphology of bone formation. Histological changes of femur specimens were observed by hematoxylin and eosin staining under a light microscope. In the GC-treated group, an empty lacunae within the necrotic bone trabeculae, bone marrow cells, including adipocytic necrosis and an accumulation of cell debris in the medullary space in most areas of the femoral head, were observed in 16/37 (43%) mice. No lesions were observed in the control group. GC, glucocorticoid.