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. 2016 Jun 6;14(2):1054–1060. doi: 10.3892/mmr.2016.5368

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Copyright: © He et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Effect of GCs treatment on osteoclast differentiation, as measured by TRAP staining. TRAP-positive multinucleated cells located at the bone surface within the bone destruction were considered to be osteoclasts. Compared with the control group, the number of osteoclasts in the areas of bone destruction was significantly decreased in the GC-treated group. The data are presented as the mean ± standard deviation (^*P<0.05, vs. the control group). GC, glucocorticoid; TRAP, tartarate-resistant acid-phosphatase; intracellular optic density value of immunohistochemical staining.