TABLE III.

Conventional 3DRT Versus IMRT Studies for Head and Neck Cancer.

Study	No. of Patients	Follow-up	Local Control	Overall Survival	PEG Tube Dependency	Hypopharynx Patients
Mok 2015 (N = 181)	3DRT N = 90,   IMRT N = 91	5 years	3DRT 58%, IMRT 75%, P = .003	3DRT 52%, IMRT 50%	3DRT 18%,   IMRT 19%	All patients
Spiotto 2014 (N = 339)	3DRT N = 125,   IMRT + SIB   N = 134,   IMRTseq N = 120	1.8 years	3DRT 76, IMRT + SIB 69%, IMRTseq 70%	3DRT 70%, IMRT +   SIB 67%,   IMRTseq 71%	3DRT 80%,   IMRT + SIB 44%,   IMRTseq 51%,   P<.0001	3DRT N = 17,   IMRT + SIB N = 8,   IMRTseq N = 7
Gupta 2012,   randomized (N = 60)	3DRT N = 28,   IMRT, N = 32	3.3 years	3DRT 88%, IMRT 81%©	3DRT 71%, IMRT 68%	Not reported	3DRT N = 8, IMRT N = 9
Nutting 2011,   randomized (N = 94)	3DRT N = 47,   IMRT N = 47	2 years	3DRT 80%, IMRT 78%©	3DRT 76%, IMRT 78%	Not reported	3DRT N = 7, IMRT N = 7

Comparisons significant when the P value is provided.

^*Locoregional control reported, not local control.

3DRT = three-dimensional conformal radiotherapy; IMRT = intensity-modulated radiotherapy; IMRT + SIB = intensity-modulated radiotherapy with simultaneous integrated boost; IMRTseq = intensity-modulated radiotherapy with sequential boost; PEG = percutaneous endoscopic gastrostomy.