TABLE III.
Study | No. of Patients | Follow-up | Local Control | Overall Survival | PEG Tube Dependency | Hypopharynx Patients |
---|---|---|---|---|---|---|
Mok 2015 (N = 181) | 3DRT N = 90, IMRT N = 91 |
5 years | 3DRT 58%, IMRT 75%, P = .003 |
3DRT 52%, IMRT 50% | 3DRT 18%, IMRT 19% |
All patients |
Spiotto 2014 (N = 339) | 3DRT N = 125, IMRT + SIB N = 134, IMRTseq N = 120 |
1.8 years | 3DRT 76, IMRT + SIB 69%, IMRTseq 70% |
3DRT 70%, IMRT + SIB 67%, IMRTseq 71% |
3DRT 80%, IMRT + SIB 44%, IMRTseq 51%, P<.0001 |
3DRT N = 17, IMRT + SIB N = 8, IMRTseq N = 7 |
Gupta 2012, randomized (N = 60) |
3DRT N = 28, IMRT, N = 32 |
3.3 years | 3DRT 88%, IMRT 81%© |
3DRT 71%, IMRT 68% | Not reported | 3DRT N = 8, IMRT N = 9 |
Nutting 2011, randomized (N = 94) |
3DRT N = 47, IMRT N = 47 |
2 years | 3DRT 80%, IMRT 78%© |
3DRT 76%, IMRT 78% | Not reported | 3DRT N = 7, IMRT N = 7 |
Comparisons significant when the P value is provided.
Locoregional control reported, not local control.
3DRT = three-dimensional conformal radiotherapy; IMRT = intensity-modulated radiotherapy; IMRT + SIB = intensity-modulated radiotherapy with simultaneous integrated boost; IMRTseq = intensity-modulated radiotherapy with sequential boost; PEG = percutaneous endoscopic gastrostomy.