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. Author manuscript; available in PMC: 2016 Jul 11.
Published in final edited form as: Cell Metab. 2014 Dec 2;20(6):1059–1068. doi: 10.1016/j.cmet.2014.11.003

Figure 5. Administration of NR prevents NIHL in a SIRT3-dependent fashion.

Figure 5

NR was administered to C57BL/6 animals at 1,000 mg/kg by intraperitoneal injection twice daily for 5 d prior to a noise exposure of 90 dB for 2 hr. SIRT3 was necessary for NR-mediated protection against transient hearing loss at 24 hr and permanent hearing loss at 14 d. Statistical analysis was performed using a two-way ANOVA followed by a Bonferroni post-test (*P < 0.05, **P < 0.01, ***P < 0.001). Error bars represent SD.