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. Author manuscript; available in PMC: 2016 Jul 11.
Published in final edited form as: Curr Pathobiol Rep. 2014 Sep 27;2(4):163–170. doi: 10.1007/s40139-014-0052-0

Figure 1.

Figure 1

Overview of MeCP2 role in liver fibrosis.

MeCP2 upregulates expression of EZH2 resulting in silencing of the PPARgamma gene; MeCP2 also positively regulates expression of histone methyltransferase, ASH1, which is involved in activation of profibrogenic genes (TGFβ1, TIMP-1, Col1a1, αSMA) by trimethylating H3K4. In addition, MeCP2 promotes liver fibrosis by repressing expression of RASAL1, PTEN and PTCH1, which causes activation of ERK and Shh-Gli1 pathways and consequently leads to HSC activation.