Table 2.
Demographic and clinical predictors of receiving the 21-gene test for breast cancer recurrence, Kaiser Permanente Northern California, Sept 2005 – June 2012a
| Characteristic | Adjusted Odds Ratio of being tested vs. not being tested (95% CI)b |
|---|---|
| Year | |
| 2005 | 0.87 (0.55,1.37) |
| 2006 | REF |
| 2007 | 2.03 (1.52,2.70)* |
| 2008 | 3.53 (2.68,4.64)* |
| 2009 | 3.92 (2.98,5.15)* |
| 2010 | 4.61 (3.53,6.03)* |
| 2011 | 4.59 (3.52,5.98)* |
| 2012 | 3.54 (2.63,4.77)* |
| Age at diagnosis | |
| <40 | 1.34 (0.94,1.89) |
| 40–<50 | 1.22 (1.04,1.44)* |
| 50–<65 | REF |
| 65–<75 | 0.42 (0.36,0.49)* |
| 75+ | 0.04 (0.02,0.06)* |
| Race/Ethnicity | |
| Asian | 1.04 (0.88,1.23) |
| Black | 0.95 (0.73,1.24) |
| Other or unknown | 0.45 (0.18,1.11) |
| White, Hispanic | 0.81 (0.65,1.02) |
| White, non-Hispanic | REF |
| Tumor size | |
| >0.5 cm to <=1.0 cm | 0.51 (0.42,0.61)* |
| >1.0 cm to <=2.0 | 1.20 (1.03,1.40)* |
| >2.0 cm | REF |
| Comorbidity score | |
| Low (0) | 1.35 (0.85,2.16) |
| Intermediate (1–2) | 1.27 (0.79,2.05) |
| High (3+) | REF |
| Census-Block group characteristics | |
| Median incomec | 1.05 (1.03,1.07)* |
| Proportion of adults with less than High School degree | 1.97 (0.99,3.90) |
a
Among breast cancer cases meeting National Comprehensive Cancer Network criteria for consideration of the 21-gene test (Oncotype DX) (n=7004). See text for inclusion criteria.
b
Odds ratios estimated using multivariate logistic regression. CI=95% confidence interval.
c
Result reflect odds for each increase of $10,000 in census block median income.