Table 1.
Clinical variables before and during add-on hydrochlorothiazide (HCTZ) treatment.
| ARB | ARB+HCTZ | p Value | |
|---|---|---|---|
| Body weight (kg) | 61.9±15.2 | 61.5±15.0 | 0.2 |
| GFR (ml/min) | 66±47 | 59±38 | 0.04 |
| SNa (mEq/l) | 141±2 | 139±3 | 0.002 |
| SK (mEq/l) | 4.4±0.6 | 4.3±0.5 | 0.1 |
| SCr (mg/dl) | 1.7±1.3 | 1.8±1.4 | 0.02 |
| SUA (mg/dl) | 6.5±1.3 | 7.1±1.3 | 0.006 |
| HbA1c (%) | 5.9±0.6 | 6.1±0.8 | 0.05 |
| PRA (ng/ml/h) | 2.5±3.2 | 4.3±3.3 | 0.01 |
| PAC (pg/ml) | 121±61 | 155±99 | 0.09 |
| Ang I (pg/ml) | 215±3 | 382±4 | 0.009 |
| Ang II (pg/ml) | 16±2 | 21±3 | 0.08 |
Ang I: angiotensin I; Ang II: angiotensin II; ARB: angiotensin receptor blocker; GFR: glomerular filtration rate; HbA1c, haemoglobin A1C; PAC: plasma aldosterone concentration; PRA: plasma renin activity; SNa, SK, SCre, SUA: serum concentrations of sodium, potassium, creatinine, uric acid, respectively; SD: standard deviation.
Values are means±SD (n=23).