Table 2.
Blood pressures, heart rates, and urinary excretion of albumin, sodium, and angiotensinogen before and during add-on hydrochlorothiazide (HCTZ) treatment.
| Variable | ARB | ARB+HCTZ | p Value | |
|---|---|---|---|---|
| SBP | Office (mmHg) | 147±9 | 124±13 | <0.0001 |
| 24-Hour (mmHg) | 132±14 | 118±15 | <0.0001 | |
| Day (mmHg) | 134±13 | 120±15 | 0.0003 | |
| Night (mmHg) | 127±17 | 113±19 | 0.0003 | |
| Night/day ratio | 0.95±0.06 | 0.94±0.10 | 0.7 | |
| DBP | Office (mmHg) | 83±12 | 76±14 | 0.04 |
| 24-Hour (mmHg) | 79±11 | 72±10 | 0.0003 | |
| Day (mmHg) | 81±11 | 75±10 | 0.0008 | |
| Night (mmHg) | 73±12 | 67±11 | 0.002 | |
| Night/day ratio | 0.91±0.06 | 0.90±0.08 | 0.7 | |
| MAP | Office (mmHg) | 104±9 | 92±13 | 0.0002 |
| 24-Hour (mmHg) | 96±10 | 87±11 | 0.0001 | |
| Day (mmHg) | 98±10 | 89±11 | 0.0003 | |
| Night (mmHg) | 91±12 | 82±13 | 0.0009 | |
| Night/day ratio | 0.93±0.06 | 0.92±0.08 | 0.6 | |
| HR | Office (rpm) | 71±15 | 74±12 | 0.2 |
| 24-Hour (rpm) | 68±8 | 68±8 | 0.9 | |
| Day (rpm) | 71±9 | 72±9 | 0.4 | |
| Night (rpm) | 61±6 | 61±8 | 0.8 | |
| Night/day ratio | 0.88±0.10 | 0.85±0.08 | 0.3 | |
| UAlbV | 24-Hour (mg/g Cre) | 419±6 | 237±7 | 0.0007 |
| Day (mg/h) | 16.07±6.14 | 9.40±6.43 | 0.003 | |
| Night (mg/h) | 16.52±4.99 | 8.79±6.44 | 0.001 | |
| Night/day ratio | 1.55±1.82 | 1.12±0.79 | 0.7 | |
| UNaV | 24-Hour (mmol/g Cre) | 152±63 | 164±63 | 0.3 |
| Day (mmol/h) | 6.45±3.77 | 6.60±2.79 | 0.9 | |
| Night (mmol/h) | 6.66±4.09 | 6.55±3.55 | 0.9 | |
| Night/day ratio | 1.23±0.90 | 1.11±0.62 | 0.9 | |
| UAGTV | 24-Hour (μg/g Cre) | 152±10 | 82±17 | 0.02 |
| Day (μg/h) | 7.06±0.01 | 2.81±0.02 | 0.001 | |
| Night (μg/h) | 3.21±0.01 | 2.73±0.01 | 0.4 | |
| Night/day ratio | 0.80±0.88 | 2.97±6.96 | 0.05 | |
ARB: angiotensin receptor blocker; /gCre: per gram creatinine; DBP: diastolic blood pressure; HR: heart rate; MAP: mean arterial pressure; SBP: systolic blood pressure; SD: standard deviation; UAlbV, UNaV, and UAGTV: urinary excretions of albumin, sodium, and angiotensinogen, respectively.
Values are means±SD (n=23).