Table 3.
Glomerulotubular balance of sodium (Na) before and during add-on hydrochlorothiazide (HCTZ) treatment.
| Variable | ARB | ARB+HCTZ | p Value |
|---|---|---|---|
| Tubular Na load (mmol/day)a | 13350±9400 | 11840±7600 | 0.03 |
| tNa (mmol/day) | 13190±9400 | 11680±7630 | 0.03 |
| UNaV (mmol/day) | 156±81 | 158±58 | 0.6 |
ARB: angiotensin receptor blocker; tNa: tubular Na reabsorption; UNaV: urinary Na excretion rate.
Values are means±SD (n=23).
a
Amount of Na filtered from the glomerulus and loaded to renal tubules was calculated as SNa×GFR, where SNa and GFR are serum Na concentration and glomerular filtration rate, respectively.