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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Muscle Nerve. 2016 May 25;54(2):264–269. doi: 10.1002/mus.25047

Figure 1.

Figure 1

Transcranial magnetic stimulation measures in C9+ participants. C9+ participants were diagnosed as having ALS or FTD according according to the El Escorial and Rascovsky criteria, with level of certainty as possible or greater. Right (squares) and left (circles) APB measures are plotted for each C9+ participant; dotted lines represent 2 SDs above and below the mean of the healthy control group. Baseline measures (A, B). A) Thresholds for eliciting a motor evoked potential in resting APB muscles with transcranial magnetic stimulation expressed as percent of stimulator output. B) Silent periods following an MEP in contracting APB muscles with TMS stimulation at 130% of threshold. Patients in the C9+ ALS subgroup had significantly shorter silent periods than controls and asymptomatic C9+ participants (asterisk - ANOVA P < 0.001; Tukey test, P < 0.05. Statistics were calculated on the average of the right and left side.) (C, D) Follow-up studies at 6 months show no significant change of C) cortical thresholds and D) silent periods. (Mean and SD measures from right and left sides are combined.)