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. Author manuscript; available in PMC: 2017 Jul 2.
Published in final edited form as: Lancet. 2016 Jan 15;388(10039):86–97. doi: 10.1016/S0140-6736(15)01121-6

Figure 1. The allelic spectrum of schizophrenia.

Figure 1

The figure depicts risk alleles for schizophrenia that have been robustly identified by genomic studies. The x-axis is the allele frequency (AF) in controls and the the y-axis is the odds ratio (genotypic relative risk). For clarity, confidence intervals are not shown. Copy number variants associated with schizophrenia are shown as blue diamonds. Single nucleotide polymorphism that are associated with SCZ and are shown as red diamonds. Alleles that confer high individual risk are rare in the population due to the effects of natural selection, whereas those conferring small effects on individual risk can become common due to genetic drift or balancing selection.