Table 2.
Distribution of select TIGAR-O risk factors in men and women with chronic pancreatitis enrolled in the NAPS2-CV study
| TIGAR-O Factors N (%) | Men (N=287) | Women (N=234) |
|---|---|---|
| Toxic-Metabolic | 239 (83.3) | 142 (60.7)* |
| Alcohol | 190 (66.4) | 84 (35.7)* |
| Tobacco | 192 (67.1) | 114 (48.5)* |
| Hyperlipidemia | 39 (13.6) | 27 (11.5) |
| Hypercalcemia | 0 (0) | 2 (0.9) |
| Medications | 3 (1) | 4 (1.7) |
| Chronic Renal Failure | 8 (2.8) | 2 (0.9) |
| Toxins | 1 (0.3) | 0 (0) |
| Idiopathic | 63 (22) | 86 (36.6)* |
| Early-onset Idiopathic | 29 (10.1) | 24 (10.2) |
| Late-onset Idiopathic | 33 (11.5) | 62 (26.4)* |
| Genetic | 23 (8) | 26 (11.1) |
| Autoimmune | ||
| Autoimmune Pancreatitis | 7 (2.5) | 7 (3) |
| Autoimmune-associated diseases | 6 (2.1) | 12 (5.2) |
| RAP and SAP associated CP | 20 (7.1) | 15 (6.4) |
| Obstructive | 36 (12.7) | 62 (26.7)* |
| Pancreas divisum | 18 (6.4) | 29 (13)** |
| Sphincter of oddi | 4 (1.4) | 16 (7.3)** |
| Post-trauma stricture | 1 (0.4) | 1 (0.5) |
| Duct obstruction | 8 (2.9) | 8 (3.7) |
| PMN | 1 (0.4) | 1 (0.5) |
| Others | 8 (2.9) | 19 (8.6)** |
| Miscellaneous | 24 (8.5) | 26 (11.2) |
RAP=Recurrent Acute Pancreatitis, SAP=Severe Acute Pancreatitis, CP=Chronic Pancreatitis; IPMN=Intra Papillary Mucinous Neoplasm
*
P value <0.001
**
P value≤0.01