Table.
Demographic and Clinical Characteristics by Group
| Characteristic | PPA-FTLD (n = 6) |
PPA-AD (n = 7) |
AMN-AD (n = 6) |
P Value |
|---|---|---|---|---|
| Age, mean (SD), y | ||||
| Onset of symptoms | 60.3 (9.5) | 69.0 (10.3) | 62.2 (10.5) | .29 |
| Clinical evaluation | 63.2 (10.0) | 72.6 (9.7) | 67.3 (9.1) | .24 |
| Death | 71.2 (7.5) | 79.1 (5.0) | 73.8 (8.9) | .16 |
| Education, mean (SD), y | 16.0 (2.8) | 15.4 (2.8) | 14.0 (3.3) | .50 |
| Sex, No. | ||||
| Male | 4 | 5 | 4 | .98 |
| Female | 2 | 2 | 2 | NA |
| Clinical severity rating, No. | ||||
| Mild impairment | 6 | 7 | 4 | .09 |
| Moderate impairment | 0 | 0 | 2 | NA |
| Object naming, BNT % correct, mean (SD) |
90.6 (14.2) | 56.9 (24.8) | 71.1 (29.7) | .07 |
| Braak stage, No. | ||||
| 0 | 3 | 0 | 0 | NA |
| 2 | 2 | 0 | 0 | NA |
| 5 | 1 | 2 | 0 | NA |
| 6 | 0 | 5 | 4a | NA |
| CERAD plaque density ratings, No. | ||||
| None | 4 | 0 | 0 | NA |
| Mild | 1 | 0 | 0 | NA |
| Frequent | 1 | 7 | 4a | NA |
Abbreviations: AD, autopsy diagnosis of Alzheimer disease neuropathology; AMN, clinical diagnosis of amnestic dementia; BNT, Boston Naming Test; CERAD, Consortium to Establish a Registry for Alzheimer’s Disease; FTLD, autopsy diagnosis of frontotemporal lobar degeneration; NA, not applicable; PPA, clinical diagnosis of primary progressive aphasia.
a
Although these patients had been given neuropathologic diagnoses of Alzheimer disease, Braak staging and CERAD ratings were not available.