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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Clin Immunol. 2016 Apr 30;168:30–36. doi: 10.1016/j.clim.2016.04.008

Fig. 5.

Fig. 5

LTa levels were determined by ELISA in the sera of C57BL/6 mice, IL14aTG mice, IL14aTG.CD19Cre.RBP-J−/− mice (labeled as IL14aTG.RBP-J−/−) and IL14aTG.BTK−/− mice at 7 and 12 months of age. Data shown are the serum levels of LTa in ng/ml for each of the mice studied. The data used in this figure for the C57BL/6 mice and the IL14aTG mice were part of a previous publication, but are included here for the sake of completeness. The studies in the IL14aTG.CD19Cre.RBP-J−/− mice and IL14aTG.BTK−/− mice were done at the same time. Serum levels of LTa were significantly increased in IL14aTG (7 M p = 0. 0363; 12 M p = 0.0104) and IL14aTG.BTK−/− mice (7 M p = 0.0032; 12 M p = 0.0024) compared to C57BL/6 mice at both time points studied, while the serum levels of LTa were statistically similar in IL14aTG.CD19Cre.RBP-J−/− mice (7 M p = 0.824; 12 M p = 0.7022) compared to C57BL/6 mice at both time points studied. There was no statistically significant difference between the serum levels of LTa in IL14aTG mice compared to IL14aTG.BTK−/− mice at either time point studied (7 M p = 0.0553; 12 M p = 0.1127). The bars on the top of the figure emphasize statistically significant differences.