Table IV.
Prognostic model for progression free survival and overall survival
Prognostic Score1 | N | HR | 95% CI Lower Limit |
95% CI Upper Limit |
p-value |
---|---|---|---|---|---|
0 | 194 | 1 | |||
2 | 103 | 1.30 | 0.97 | 1.76 | 0.08 |
4 | 14 | 1.41 | 0.76 | 2.62 | 0.28 |
5 | 38 | 1.66 | 1.13 | 2.46 | 0.01 |
6 | 12 | 2.21 | 1.19 | 4.11 | 0.01 |
7 | 35 | 2.34 | 1.58 | 3.47 | <0.0001 |
9 | 3 | 1.79 | 0.44 | 7.24 | 0.41 |
11 | 18 | 5.47 | 3.26 | 9.19 | <0.0001 |
Progression-free Survival Risk Groups | |||||
Low (Score 0) | 194 | 1 | |||
Intermediate (Score 2,4,5) | 155 | 1.40 | 1.08 | 1.82 | 0.01 |
High (Score 6,7,9) | 50 | 2.28 | 1.61 | 3.22 | <0.0001 |
Very high (Score 11) | 18 | 5.47 | 3.26 | 9.19 | <0.0001 |
Contrast | |||||
Intermediate vs. High | 0.61 | 0.43 | 0.87 | 0.006 | |
Intermediate vs. Very high | 0.26 | 0.15 | 0.43 | <0.0001 | |
High vs. Very high | 0.42 | 0.24 | 0.73 | 0.002 | |
Overall Survival Risk Groups | |||||
Low (Score 0) | 199 | 1 | |||
Intermediate (Score 2,4,5) | 156 | 1.34 | 1.02 | 1.76 | 0.03 |
High (Score 6,7,9) | 50 | 2.11 | 1.47 | 3.03 | <0.0001 |
Very high (Score 11) | 18 | 3.94 | 2.32 | 6.68 | <0.0001 |
Contrast | |||||
Intermediate vs. High | 0.63 | 0.44 | 0.91 | 0.02 | |
Intermediate vs. Very high | 0.34 | 0.20 | 0.58 | <0.0001 | |
High vs. Very high | 0.54 | 0.30 | 0.96 | 0.03 |
N = number; HR = hazard ratio; CI = confidence interval; CR = complete response; PR = partial response; KPS = Karnofsky performance status; alloHCT=allogeneic haematopoietic cell transplantation; autoHCT= autologous haematopoietic cell transplantation;
Prognostic score determined by following:
KPS≥80 = 0 point, KPS <80 = 4 points.
Disease status CR or PR = 0 point, Chemoresistant = 5 points
Time from autoHCT to alloHCT ≥12 months = 0 point, <12 months = 2 points.