Table VI.
Studies reporting outcomes of allogeneic transplantation in diffuse large B-cell lymphoma patients who received a prior autograft.
Study | N | MA vs. RIC (N) |
NRM | PFS | OS | Factors predicting better PFS or OS |
---|---|---|---|---|---|---|
Van Kampen et al (2011) | 101 | 37 vs. 64 | 28% (3-year) |
42% (3-year) |
54% (3-year) |
TIBAR>1-year, normal LDH, peripheral blood graft |
Rigacci et al (2012) | 165 | 49 vs. 116 | 28% (not specified) |
31% (5-year) |
39% (5-year) |
Chemosensitive disease, matched sibling donors |
Kim et al (2014) | 30 | 7 vs. 23 | 17% (not specified) |
38% (5-year) |
43% (5-year) |
Chemosensitive disease, good performance status |
Current analysis | 503 | 127 vs. 376 | 31% (5-year) |
29% (5-year) |
34% (5-year) |
KPS>80, chemosensitive disease, RIC, TIBAA >1-year |
MA=myeloablative conditioning; RIC=reduced intensity conditioning, NRM=non-relapse mortality, PFS=progression-free survival; OS=overall survival; LDH=lactate dehydrogenase; TIBAA=time-interval between autologous and allogeneic transplantation; TIBAR=time interval between autologous transplant and post-autograft relapse; KPS=Karnofsky performance score.