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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Semin Cell Dev Biol. 2016 Jan 11;59:35–45. doi: 10.1016/j.semcdb.2016.01.004

Figure 5. Schematic diagram of effects of adjudin on Sertoli cell cytoskeleton in the seminiferous epithelium.

Figure 5

In normal Sertoli cells of the seminiferous epithelium, MTs serve as the tracks for the transport of developing germ cells across the BTB and the seminiferous epithelium throughout spermatogenesis. Actin microfilaments are also present along these tracks, serving as the support and vehicle for germ cell transport across the epithelium. Using adjudin as a model to study germ cell transport, we have provided evidence that germ cell transport is disrupted due to the loss of MT track and actin support as briefly summarized herein.