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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Alzheimer Dis Assoc Disord. 2016 Jul-Sep;30(3):195–202. doi: 10.1097/WAD.0000000000000137

Table 2.

Generalized Linear Models: Regression coefficients for standardized memory score by AD-GRS and age.

Non-Hispanic White
N=7,172
β (95% CI)		 Non-Hispanic Black
N=1,081
β (95% CI)
AD-GRS with APOE AD-GRS without APOE AD-GRS with APOE AD-GRS without APOE
AD-GRS (per 0.1 difference) −0.035** (−0.050, −0.020) −0.016 (−0.036, 0.005) −0.059* (−0.101, −0.017) −0.049 (−0.12, 0.023)
Current Age (in decades) −0.325** (−0.342, −0.308) −0.356** (−0.378, −0.334) −0.427** (−0.475, −0.379) −0.464** (−0.522, −0.406)
Current Age2 −0.100** (−0.120, −0.090) −0.110** (−0.130, −0.090) −0.110** (−0.140, −0.080) −0.130** (−0.170, −0.080)
AD-GRS* Current Age −0.058** (−0.074, −0.043) −0.029* (−0.050, −0.007) −0.050 (−0.106, 0.006) −0.005 (−0.080, 0.070)
AD-GRS* Current Age2 −0.002* (−0.003, −0.001) −0.001 (−0.003, 0.001) 0.000 (−0.004, 0.004) 0.002 (−0.005, 0.009)

All models are additionally adjusted for: baseline age (centered at 70 years), gender and eigenvectors.

*

p-value <0.05;

**

p-value <0.001

AD-GRS = Alzheimer’s disease genetic risk score