Table 3.
Pooled Logistic Models: Odds Ratios for the association of the AD-GRS, race, and memory score (in 2004) with death and dropout from 2010 to 2012.
| Death OR (95% CI) |
Death OR (95% CI) |
Drop-out OR (95% CI) |
Drop-out OR (95% CI) |
|
|---|---|---|---|---|
| AD-GRS (0.1 increase) | 0.98 (0.63, 1.52) | 1.02 (0.68, 1.55) | 1.03 (0.67, 1.59) | 1.05 (0.70, 1.57) |
| Black race | 0.44 (0.096, 2.01) | 0.50 (0.12, 2.09) | 0.59 (0.14, 2.54) | 0.63 (0.16, 2.51) |
| AD-GRS* Black race | 0.83 (0.36, 1.88) | 0.73 (0.37, 1.43) | 1.04 (0.46, 2.35) | 0.98 (0.51, 1.87) |
| Memory Score | 0.42* (0.24, 0.73) | 0.44* (0.26, 0.74) | 0.48* (0.28, 0.81) | 0.49* (0.3, 0.8) |
| Black race* Memory Score | 1.53 (0.52, 4.47) | 1.20 (0.76, 1.91) | 0.89 (0.31, 2.55) | 0.79 (0.50, 1.26) |
| AD-GRS* Memory Score | 1.19 (0.77, 1.84) | 1.13 (0.76, 1.69) | 1.10 (0.73, 1.67) | 1.08 (0.74, 1.58) |
| AD-GRS* Black race* Memory Score | 0.76 (0.26, 2.18) | - | 0.88 (0.31, 2.50) | - |
All models are additionally adjusted for baseline age (centered at 70 years), current age, current age2, gender, and eigenvectors.
*
p-value <0.05;
**
p-value <0.001
AD-GRS = Alzheimer’s disease genetic risk score