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. Author manuscript; available in PMC: 2016 Aug 22.
Published in final edited form as: Oncogene. 2016 Jan 11;35(33):4335–4344. doi: 10.1038/onc.2015.496

Figure 7. A model depicting the hierarchical regulatory network of FOXA1, GATA2, and AR.

Figure 7

FOXA1 acts up-stream to GATA2 and AR by functioning as a pioneer factor that defines and reprograms both GATA2 and AR cistromes. By contrast, GATA2 and AR are co-activators of each other, which also potentiate, but do not reprogram, FOXA1 binding to chromatin. Our study reveal distinct molecular mechanisms by which FOXA1 and GATA2 regulate AR cistrome and suggest a unique, reprogramming, role of FOXA1 that is central to hormonal regulation of gene expression in prostate cancer.