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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Proteins. 2016 Jan 27;84(Suppl 1):20–33. doi: 10.1002/prot.24982

Figure 3. Difficult evolutionary target classifications.

Figure 3

Similar structural elements between target and template are colored in rainbow, with insertions in gray. A) The target T0824-D1 retains a similar placement of the active site (black sidechains) and unusual structure feature (magenta), yet has a significant deterioration of the fold present in B) the closest template (1g8t), active site marked by black sphere. C) The target T0832 retains a similar placement of the active site (black sidechains), yet has a significant deterioration of the fold present in D) the closest template (1dmw). E) A relatively well-predicted new fold of the swapped domain in target T0820-D2 (rainbow) can be modeled over a significant portion of the fold by F) a partially detected domain template (2f23).