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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Proteins. 2016 Jan 27;84(Suppl 1):20–33. doi: 10.1002/prot.24982

Figure 4. Evolutionary classification of CASP11 targets using ECOD.

Figure 4

A) Targets are distributed into ECOD hierarchy, with 42 classified at the family level with closely related structures, 50 classified at the H-group level with more distantly related structure homologs, 28 classified at the X-group level with structures having similar topology, but questionable homology, and 6 targets classified as new folds. B) The distribution of targets into ECOD architectures shows relatively equal distribution among traditionally categorized classes of all-α (highlighted pink), all-β (highlighted lavender), α/β (highlighted light blue) and α+β (highlighted light green). C). Some ECOD architectures are overrepresented in CASP11 targets (blue bars) and some are underrepresented in CASP11 targets (red bars) as compared to all ECOD classified PDB structures.