Table 3.
Hemodynamic parameters of patients with severe sepsis or septic shock according to ICU outcome
| Parameters at H6 | Survivors | MOF deaths | Late deaths | P value |
|---|---|---|---|---|
| N | 64 | 17 | 22 | − |
| Time of death (days) | − | 18 [12; 37] | 2 [1; 4] | c*** |
| SOFA | 6 [4; 9] | 8 [5; 11] | 14 [12; 15] |
a*** b ns c*** |
| SAPS II | 43 [33; 54] | 51 [43; 60] | 77 [63; 91] |
a*** b ns c*** |
| Mechanical ventilation (%) | 67 | 75 | 90 |
a ns b ns c ns |
| Norepinephrine dose (μg/Kg/min) | 0.0 [0.0; 0.30] | 0.10 [0.0; 0.25] | 0.65 [0.50; 3.25] |
a***
b ns c *** |
| MAP (mmHg) | 73 [67; 80] | 70 [64; 78] | 70 [66; 83] |
a ns b ns c ns |
| CI (L/min/m2) | 2.6 [2.1; 3.3] | 2.4 [1.9; 2.8] | 2.7 [1.9; 3.5] |
a ns b ns c ns |
| Urinary output (mL/Kg/h) | 1.0 [0.6; 1.4] | 0.7 [0.5; 0.8] | 0.1 [0; 0.5] |
a*** b ns c*** |
| Lactate level (mmol/L) | 1.5 [0.9; 2.3] | 1.5 [1.2; 2.0] | 6.1 [2.7; 14.1] |
a*** b ns c*** |
| Gradient (°C) | ||||
| Central-to-toe | 10.4 [4.6; 12.9] | 7.0 [3.7; 12.2] | 12.9 [10.5; 14.5] |
a** b ns c** |
| Central-to-knee | 6.8 [4.6; 8.2] | 5.2 [4.2; 7.2] | 6.7 [3.9; 9.1] |
a ns b ns c ns |
| Gradient (°C) | ||||
| Toe-to-room | 3.9 [0.5; 7.2] | 4.0 [0.5; 9.0] | −0.2 [−1.1; 1.3] |
a*** b ns c** |
| Knee-to-room | 6.8 [5.1; 8.7] | 7.9 [6.4; 8.5] | 5.5 [4.1; 7.8] |
a* b ns c* |
| Index CRT (s) | 1.8 [1.0; 3.1] | 2.0 [1.5; 3.3] | 4.0 [2.1; 5.9] |
a** b ns c ns |
| Knee CRT (s) | 2.8 [1.4; 4.3] | 3.1 [2.2; 4.7] | 5.1 [2.9; 9.0] |
a*** b ns c* |
| Mottling score | ||||
| 0–1 | 51 | 12 | 7 | a*** |
| 2–3 | 5 | 2 | 7 | b ns |
| 4–5 | 1 | 1 | 4 | c* |
Data are expressed as number, percentage or median and IQRs
SOFA Sequential Organ Failure Assessment, SAPS II Simplified Acute Physiology Score, MAP mean arterial pressure, CI cardiac index, CRT capillary refill time
Statistical analysis, a survivors vs MOF deaths (multi-organ failure), b survivors vs late deaths, c deaths from MOF vs late deaths
* P < 0.05, ** P < 0.01, *** P < 0.001