Table 1.
Time of IL-8 release and CD86 expression of the selected drugs in THP-1 assay.
| Chemical | CV75 (μg/ml) | Statistical significant IL-8 release | CD86 expression |
|---|---|---|---|
| Streptozotocin | >2000 | 24 h | 24 h |
| Sulfamethoxazole | >1000 | 48 h | 48 h |
| Procainamide | >2000 | 24 h | 24 h |
| Ofloxacin | >1000 | 24 h | 24 h |
| Neomycin | >2000 | 24 h | – |
| Clonidine | 750 | 24 h | 24h |
| Methyl salicylate | >1000 | 24 h | 24h |
| Probenecid | 600 | 24 h | 48h |
| Metformin | >2000 | – | – |
106/ml cells were treated for 24–48 h with increasing concentrations of the selected drugs. Cell viability was assessed by PI staining. CV75 (the concentration resulting in 75% of cells viability compared to vehicle treated cells) was calculated by linear regression analysis of data. IL-8 release was measured by ELISA. CD86 expression was evaluated by flow cytometric analysis. Original data are present in Corti et al. (2015).
Legend: – no induction observed.