Table 1.
Interleukin 6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-α) serum levels and IL-6, TNF-α, TLR-1, and TLR-3 mRNA expression of rats subchronically treated with OAO-ASA (8).
| Groupn | Serum concentration (pg/ml) | mRNA expression∗ (%) | ||||
|---|---|---|---|---|---|---|
| IL-6 | TNF-α | IL-6 | TNF-α | TLR-1 | TLR-3 | |
| Control | 55.4 ± 1.6 | 1494 ± 332 | 100 ± 15 | 100 ± 7 | 100 ± 10 | 100 ± 13 |
| OAO-ASA (8) | 9.3 ± 0.8∗∗ | 1099 ± 201 | 60 ± 5∗∗ | 11 ± 29∗∗ | 138 ± 13∗∗ | 108 ± 19 |
TLR-1, TLR-3 = Toll-like receptor 1, Toll-like receptor 3, values are means ± SEM, n = number of animals: 10, ∗ = values expressed as a ratio: the gene/GAPDH, control = rats treated with 5% Tween 80, OAO-ASA (8) = rats treated with OAO-ASA (8) (dissolved in 5% Tween 80) in the dose of 30 mg/kg (p.o.) for 4 weeks, ∗∗ = vs. control, p < 0.05.