Table 3. Sensitivity and specificity for AMI with 95% CI for each assay at the enrollment time point.
Performance of AMI detection in a population with detectable TnI (for each assay) | |||
---|---|---|---|
Triage TnI (n=968) | PathFast TnI (n = 989) | Singulex TnI (n = 288) | |
Sensitivity (95% CI) | 79.3 (70.5, 86.4) | 76.7 (76.4, 84.5) | 92.0 (83.4, 97.0) |
Specificity (95% CI) | 91.1 (89.0, 92.9) | 92.8 (90.9, 94.4) | 89.7 (84.8, 93.4) |
C-Statistics (95% CI) | 0.90 (0.86, 0.93) | 0.88 (0.84, 0.92) | 0.96 (0.93, 0.99) |
Triage vs Singulex | PathFast vs Singulex | Triage vs PathFast | |
Comparison | P = 0.0002, n = 74 | P < 0.0001, n = 65 | P = 0.1770, n = 130 |
Positive defined as ≥20, 29, and 10.2 pg/mL for Triage, PathFast, and Singulex, respectively.
Abbreviations: AMI, acute myocardial infarction; TnI, troponin; CI, confidence interval.