Figure 2.

(a–c) Two-dimensional transition maps of the adenylate kinase protein at three different GdmCl concentrations, as indicated. (d–f) One-dimensional free energy maps of adenylate kinase showing five of the six metastable states as well as the transitions between them that contain at least 10% of the flux from beginning to end (or vice versa). The color bar indicates the rate of flux, whereas the line widths show the relative productive flux along each pathway. This figure is adapted from (26) with permission. To see this figure in color, go online.