Table 2.
Age, scores, and results of laboratory parameters, of hemodynamic monitoring (PiCCO-System), and of dynamic measurement of the liver function (LiMON-System) at inclusion or on day 1 (before granulocyte therapy) of survivors and nonsurvivors (median/0.25–0.75 quartile).
| Survivors (n = 5) |
Nonsurvivors (n = 5) |
Statistical significance (p) | |
|---|---|---|---|
| Age (years) | 59 (57–76) | 67 (66–72) | n.s. |
| Surgery/no surgery | 4/1 | 5/0 | |
| APACHE II at ICU arrival/at inclusion | 20.5 (17.8–25)/22 (22–34) | 27 (27–33)/30 (28–32) | n.s. |
| SOFA at inclusion | 8 (6–10) | 14 (13–14) | n.s. |
| SAPS II at inclusion | 47 (44–62) | 74 (73–78) | 0.032 |
| MODS at inclusion | 8 (7–12) | 12 (11–13) | n.s. |
| Bilirubin (µmol/L) | 12 (11–17) | 44 (30–145) | 0.016 |
| ALAT (U/L) | 32 (20–45) | 37 (30–219) | n.s. |
| ASAT (U/L) | 62 (44–74) | 105 (52–669) | n.s. |
| Ammonia (mmol/L) | 36 (32–62) | 39 (38–61) | n.s. |
| PCT (ng/mL) | 7.3 (0.5–43) | 10.4 (7.4–14.6) | n.s. |
| Leukocytes (GpT/L) | 18.1 (14.8–18.1) | 16.2 (13.9–22.2) | n.s. |
| Thrombocytes (GpT/L) | 159 (89–278) | 125 (47–269) | n.s. |
| Prothrombin time as INR | 1.09 (1.01–1.1) | 1.32 (1.11–1.33) | n.s. |
| Activated partial thromboplastin time (s) | 36 (33–49) | 48 (45–54) | n.s. |
| Creatinine (µmol/L) | 143 (79–238) | 178 (165–213) | n.s. |
| Urea (mmol/L) | 15.7 (5.7–16) | 14.7 (13.8–24.9) | n.s. |
| Lactate (mmol/L) | 1.0 (0.9–1.8) | 2.0 (1.6–2.1) | n.s. |
| Complement C3 (g/L) | 1.1 (1.0–1.8) | 0.7 (0.5–1.0) | n.s. |
| Complement C4 (g/L) | 0.5 (0.4–0.9) | 0.4 (0.2–0.5) | n.s. |
| HLA-DR/CD-14 positive cells (expression/cell) | 6413 (5890–6970) | 8980 (7640–9590) | n.s. |
| Cardiac index (L/m2/min) | 3.5 (3.3–4.0) | 2.5 (2.5–3.4) | n.s. |
| Stroke volume index (mL/m2) | 48 (43–51) | 29 (28–39) | n.s. |
| MAP (mmHg) | 92 (84–93) | 71 (69–85) | n.s. |
| Norepinephrine (µg/kg/min) | 0.13 (0.06–0.21) | 0.36 (0.29–0.51) | 0.032 |
| ICG-PDR on day 1 (%)/ICG-PDR/CI | 14.4 (13.3–17.2)/5.6 (4.9–5.7) | 5.3 (2.5–11.9)/2.9 (1.1–2.9) | 0.048/0.05 |
ALAT: alanine aminotransferase.
APACHE: Acute Physiology and Chronic Health Evaluation.
ASAT: aspartate aminotransferase.
CI: cardiac index.
HLA: human leukocyte antigen.
ICG-PDR: indocyanine green plasma disappearance rate.
MAP: mean arterial pressure.
MODS: multiorgan dysfunction syndrome (score).
n.s.: not (statistically) significant.
PCT: procalcitonin.
SAPS: simplified acute physiology score.
SOFA: sequential organ failure assessment (score).