Table 3.

Cytokines values before the first extracorporeal granulocyte therapy, after the second extracorporeal granulocyte therapy, and after 7 days (median/0.25–0.75 quartile).

Cytokine	Before first extracorporeal therapy (day 1) (n = 10, pg/mL)	After second extracorporeal therapy (day 3) (n = 8, pg/mL)	After 7 days (day 8) (n = 7, pg/mL)
IL-6	57 (41–159)	78 (45–154)	28 (26–62)#
IL-8	40 (28–53)	57 (38–118)	30 (29–36)
TNF-alpha	30 (22–40)	22 (19–26)	15 (13–17)∗#
IL-10	15 (8–20)	11 (8–13)	3 (3–8)

^∗Statistically significant (p = 0.028) compared to day 1 (before first extracorporeal treatment).

^#Statistically significant (p < 0.05) compared to the end of second extracorporeal treatment.

IL: interleukin.

TNF: tumor necrosis factor.