Table 1.
Influence of Escherichia coli Nissle 1917 (Mutaflor) and rifaximin on morphological signs of colonic damage in rats without or with acetic acid-induced colitis observed 8 days after rectal administration of saline or acetic acid solution (colitis).
| Morphological changes | ||||
|---|---|---|---|---|
| Grading of colonic damage (0–2) | Inflammatory infiltration (0–3) | Depth of damage (0–3) | Fibrosis (0–3) | |
| Saline (control) | 0 | 0 | 0 | 0 |
| Mutaflor | 0 | 0 | 0 | 0 |
| Rifaximin | 0 | 0 | 0 | 0 |
| Rifaximin + Mutaflor | 0 | 0 | 0 | 0 |
| Colitis + NaCl | 3 | 2-3 | 2 | 1-2 |
| Colitis + Mutaflor | 3 | 2-3 | 1-2 | 1 |
| Colitis + rifaximin | 2-3 | 1-2 | 1-2 | 1 |
| Colitis + rifaximin + Mutaflor | 2 | 1 | 1 | 0-1 |
Numbers represent the predominant histological grading in each group.