Figure 4.

(a) Main and total effect ($S_{k_i},S_{T_{K_i}}$) on the value of υ_r due to a change in rate constant k_i. (Inset) Changes in υ_r in function of the changes on $k_2$ for a range of two orders of magnitude below and above its nominal value (star). (b) Codon elongation rate obtained from stochastic simulations ($k_{\text{stoch}}$) versus the codon elongation rate constant ($k_{\text{eff}}$; open circles). Each data point corresponds to one of the 61 codons taking part in the translation elongation. Linear regression line is represented by a continuous line. The Pearson correlation coefficient (r) and p-value are indicated. The dashed line is the one-to-one function for comparison. The signal/noise from $k_{\text{stoch}}$ corresponding to each codon is represented by the dots and remains higher than 1 for all codons, starting to stabilize for the codons with higher elongation rates. To see this figure in color, go online.