Table 1.
δ Receptor agonist potencies for inhibiting cAMP production and recruiting β‐arrestin 2 at the δ receptor expressed in HEK cells and CHO cells respectively
| NIH11082 | TAN‐67 | KNT‐127 | Leu‐Enk | DPDPE | ARM390 | SNC162 | SNC80 | |
|---|---|---|---|---|---|---|---|---|
| pIC50 (cAMP) | 5.2 ± 0.2 (5) | 8.6 ± 0.2 (6) | 8.7 ± 0.1 (4) | 8.5 ± 0.1 (4) | 8.2 ± 0.1 (5) | 6.9 ± 0.1 (5) | 8.4 ± 0.1 (22) | 8.2 ± 0.2 (7) |
| pEC50 (βARR2) | 4.9 ± 0.2 (4) | 7.9 ± 0.1 (4) | 8.5 ± 0.1 (5) | 7.6 ± 0.1 (5) | 7.6 ± 0.1 (4) | 6.5 ± 0.1 (6) | 7.9 ± 0.1 (4) | 8.2 ± 0.1 (4) |
| Efficacy (%) | 36 ± 4 | 41 ± 3 | 71 ± 2 | 100 ± 4 | 100 ± 1 | 103 ± 7 | 137 ± 7 | 142 ± 9 |
Potency of δ receptor agonists to inhibit cAMP production is depicted as concentration of 50% inhibition (pIC50) and the SEM. Potency (pEC50) and efficacy (normalized to DPDPE and leu‐enkephalin) of δ receptor agonists to recruit β‐arrestin 2 are depicted with SEM. The number of repetitions for each drug is indicated in parentheses.