Fig. 4.

Macroscopic (a) and microscopic (b) observations of bile liquid crystallization and gallstone formation in hyperthyroidism, hypothyroidism, and euthyroidism mice

In hyperthyroidism, both characteristic cholesterol monohydrate crystals (arrows) and gallstones (arris) can be found (6/6, 100%). In hypothyroidism, only cholesterol monohydrate crystals can be detected (5/6, 83%). In most mice with euthyroidism, non-birefringent tubular crystals can be detected, but cholesterol monohydrate crystals can only be observed in 2/6